Concurrent Channel Probing and Data Transmission in Full-duplex MIMO Systems

An essential step for achieving multiplexing gain in MIMO downlink systems is to collect accurate channel state information (CSI) from the users. Traditionally, CSIs have to be collected before any data can be transmitted. Such a sequential scheme incurs a large feedback overhead, which substantially limits the multiplexing gain especially in a network with a large number of users. In this paper, we propose a novel approach to mitigate the feedback overhead by leveraging the recently developed Full-duplex radios. Our approach is based on the key observation that using Full-duplex radios, when the base-station (BS) is collecting CSI of one user through the uplink channel, it can use the downlink channel to simultaneously transmit data to other (non-interfering) users for which CSIs are already known. By allowing concurrent channel probing and data transmission, our scheme can potentially achieve a higher throughput compared to traditional schemes using Half-duplex radios. The new flexibility introduced by our scheme, however, also leads to fundamental challenges in achieving throughout optimal scheduling. In this paper, we make an initial effort to this important problem by considering a simplified group interference model. We develop a throughput optimal scheduling policy with complexity $O((N/I)^I)$, where $N$ is the number of users and $I$ is the number of user groups. To further reduce the complexity, we propose a greedy policy with complexity $O(N\log N)$ that not only achieves at least 2/3 of the optimal throughput region, but also outperforms any feasible Half-duplex solutions. We derive the throughput gain offered by Full-duplex under different system parameters and show the advantage of our algorithms through numerical studies.Comment: Technical repor

Optimal Coordinated Dispatching Strategy of Multi-Sources Power System with Wind, Hydro and Thermal Power Based on CVaR in Typhoon Environment

Typhoons and other natural disasters affect the normal operation of power systems thus it is an important goal for strong and intelligent power grid construction to improve the ability of power systems to resist typhoons and other natural disasters. Especially, an effective coordinated and optimized dispatching strategy for a multi-source power system is greatly helpful to cope with the impact of typhoons and other natural disasters on power system operation. Given this background, a typhoon wind circle model considering the temporal and spatial distribution of typhoons is established to obtain the input wind speed of the wind farm at first. Second, based on the initial input wind speed of wind farms, a typical scenario set of wind power output is constructed to reflect its fluctuation and uncertainty. Next, an optimal coordinated dispatching model of a multi-source power system with wind, hydro and thermal power based on the conditional value at risk (CVaR) is established with the target of minimizing the total cost of system dispatching, in which a 72 h pre-dispatching mode is studied to optimize the system operation for 72 h on the day before, on and after the typhoon. Finally, a revised 24-node transmission network system in a coastal area with typhoon is served as a case for demonstrating the effectiveness of the proposed model, and the simulation result shows that the proposed model could take the advantages of the coordination and complementarity of multi-sources power system and decrease the total cost of system dispatching and improve the renewable energy consumption level

Genetic Evolution and Variation of Human Adenovirus Serotype 31 Epidemic Strains in Beijing, China, during 2010–2022

Human adenovirus serotype 31 (HAdV-31) is closely associated with gastroenteritis in children and can cause fatal systemic disseminated diseases in immunocompromised patients. The lack of genomic data for HAdV-31, especially in China, will greatly limit research on its prevention and control. Sequencing and bioinformatics analyses were performed for HAdV-31 strains from diarrheal children in Beijing, China, during 2010–2022. Three capsid protein genes (hexon, penton, and fiber) were obtained in 37 cases, including one in which the whole genome was sequenced. HAdV-31 strains clustered into three distinct clades (I–III) in a phylogenetic tree constructed based on concatenated genes and the whole genome; the endemic strains only gathered into clade II, and most of the reference strains clustered into clade I. Compared with penton and hexon, fiber had a faster evolutionary rate (1.32 × 10−4 substitutions/site/year), an earlier divergence time (1697), lower homology (98.32–100% at the amino acid level), and greater genetic variation (0.0032). Four out of the six predicted positive selection pressure codons were also in the knob of fiber. These results reveal the molecular evolution characteristics and variations of HAdV-31 in Beijing, and fiber may be one of the main evolution driving forces

Molecular typing and characterization of a novel genotype of EV-B93 isolated from Tibet, China.

EV-B93 is a novel serotype within the Enterovirus B species and is uncommon worldwide. Currently, only one full-length genomic sequence (the prototype strain) has been deposited in the GenBank database. In this study, three EV-B93 were identified, including one from an acute flaccid paralysis (AFP) patient (named 99052/XZ/CHN/1999, hereafter XZ99052) and two from healthy children (named 99096/XZ/CHN/1999 and 99167/XZ/CHN/1999, hereafter XZ99096 and XZ99167, respectively) from Tibet in 1999 during the polio eradication program. The identity between the nucleotide and amino acid sequences of the Tibet EV-B93 strain and the EV-B93 prototype strain is 83.2%-83.4% and 96.8%-96.9%, respectively. The Tibet EV-B93 strain was found to have greater nucleotide sequence identity in the P3 region to another enterovirus EV-B107 as per a phylogenetic tree analysis, which revealed that recombination occurred. Seroepidemiology data showed that EV-B93 has not produced an epidemic in Tibet and there may be susceptible individuals. The three Tibet EV-B93 strains are temperature-resistant with prognosticative virulence, suggesting the possibility of a potential large-scale outbreak of EV-B93. The analyzed EV-B93 strains enrich our knowledge about this serotype and provide valuable information on global EV-B93 molecular epidemiology. What is more, they permit the appraisal of the serotype's potential public health impact and aid in understanding the role of recombination events in the evolution of enteroviruses

Genetic characterization and molecular epidemiological analysis of novel enterovirus EV-B80 in China

Abstract Enterovirus B80 (EV-B80) is a newly identified serotype belonging to the enterovirus B species. To date, only two full-length genomic sequences of EV-B80 are available in GenBank, and few studies on EV-B80 have been conducted in China or worldwide. More information and research on EV-B80 is needed to assess its genetic characteristics, phylogenetic relationships, and association with enteroviral diseases. In this study, we report the phylogenetic characteristics of three Xinjiang EV-B80 strains and one Tibet EV-B80 strain in China. The full-length genomic sequences of four strains show 78.8–79% nucleotide identity and 94–94.2% amino acid identity with the prototype of EV-B80, indicating a tendency for evolution. Based on a maximum likelihood phylogenetic tree based on the entire VP1 region, three genotypes (A–C) were defined, revealing the possible origin of EV-B80 strains in the mainland of China. Recombination analysis revealed intraspecies recombinations in all four EV-B80 strains in nonstructural regions along with two recombination patterns. Due to the geographic factor, the coevolution of EV-B strains formed two different patterns of circulation. An antibody seroprevalence study against EV-B80 in two Xinjiang prefectures also showed that EV-B80 strains were widely prevalent in Xinjiang, China, compared to other studies on EV-B106 and EV-B89. All four EV-B80 strains are not temperature sensitive, showing a higher transmissibility in the population. In summary, this study reports the full-length genomic sequences of EV-B80 and provides valuable information on global EV-B80 molecular epidemiology

Genetic Diversity Analysis of Coxsackievirus A8 Circulating in China and Worldwide Reveals a Highly Divergent Genotype

Coxsackievirus A8 (CV-A8) is one of the pathogens associated with hand, foot and mouth disease (HFMD) and herpangina (HA), occasionally leading to severe neurological disorders such as acute flaccid paralysis (AFP). Only one study aimed at CV-A8 has been published to date, and only 12 whole-genome sequences are publicly available. In this study, complete genome sequences from 11 CV-A8 strains isolated from HFMD patients in extensive regions from China between 2013 and 2018 were determined, and all sequences from GenBank were retrieved. A phylogenetic analysis based on a total of 34 complete VP1 sequences of CV-A8 revealed five genotypes: A, B, C, D and E. The newly emerging genotype E presented a highly phylogenetic divergence compared with the other genotypes and was composed of the majority of the strains sequenced in this study. Markov chain Monte Carlo (MCMC) analysis revealed that genotype E has been evolving for nearly a century and somehow arose in approximately 2010. The Bayesian skyline plot showed that the population size of CV-A8 has experienced three dynamic fluctuations since 2001. Amino acid residues of VP1100N, 103Y, 240T and 241V, which were embedded in the potential capsid loops of genotype E, might enhance genotype E adaption to the human hosts. The CV-A8 whole genomes displayed significant intra-genotypic genetic diversity in the non-capsid region, and a total of six recombinant lineages were detected. The Chinese viruses from genotype E might have emerged recently from recombining with European CV-A6 strains. CV-A8 is a less important HFMD pathogen, and the capsid gene diversity and non-capsid recombination variety observed in CV-A8 strains indicated that the constant generation of deleterious genomes and a constant selection pressure against these deleterious mutations is still ongoing within CV-A8 quasispecies. It is possible that CV-A8 could become an important pathogen in the HFMD spectrum in the future. Further surveillance of CV-A8 is greatly needed

Genomic Epidemiology and Transmission Dynamics of Global Coxsackievirus B4

The aim of this study was to determine the global genetic diversity and transmission dynamics of coxsackievirus B4 (CVB4) and to propose future directions for disease surveillance. Next-generation sequencing was performed to obtain the complete genome sequence of CVB4, and the genetic diversity and transmission dynamics of CVB4 worldwide were analyzed using bioinformatics methods such as phylogenetic analysis, evolutionary dynamics, and phylogeographic analysis. Forty complete genomes of CVB4 were identified from asymptomatic infected individuals and hand, foot, and mouth disease (HFMD) patients. Frequent recombination between CVB4 and EV-B multiple serotypes in the 3Dpol region was found and formed 12 recombinant patterns (A-L). Among these, the CVB4 isolated from asymptomatic infected persons and HFMD patients belonged to lineages H and I, respectively. Transmission dynamics analysis based on the VP1 region revealed that CVB4 epidemics in countries outside China were dominated by the D genotype, whereas the E genotype was dominant in China, and both genotypes evolved at a rate of > 6.50 × 10−3 substitutions/site/year. CVB4 spreads through the population unseen, with the risk of disease outbreaks persisting as susceptible individuals accumulate. Our findings add to publicly available CVB4 genomic sequence data and deepen our understanding of CVB4 molecular epidemiology